Population pharmacokinetic analysis and dosing optimization of polymyxin B in critically ill patients

Population pharmacokinetic analysis and dosing optimization of polymyxin B in critically ill patients

Objectives: Since the global broadcast of multidrug-resistant gram-negative bacteria is accelerating, the use of Polymyxin B is sharply increasing, especially in critically ill patients. Unsatisfactory therapeutic effects were obtained because of the abnormal physiological function in critically ill...

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Bibliographic Details
Main Authors: Danhong Liang, Zhi Liang, Guoliang Deng, Anfen Cen, Dandan Luo, Chen Zhang, Suiqin Ni
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
polymyxin B
critically ill patients
population pharmacokinetics
albumin levels
dosing optimization
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1122310/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1122310/full

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