The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner

The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner

The parasitic worm-derived immunomodulator, ES-62 rescues defective levels of IL-10-producing regulatory B cells (Bregs) and suppresses chronic Th1/Th17-driven inflammation to protect against joint destruction in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis. Such autoimmu...

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Bibliographic Details
Main Authors: Margaret M. Harnett, James Doonan, Anuradha Tarafdar, Miguel A. Pineda, Josephine Duncombe-Moore, Geraldine Buitrago, Piaopiao Pan, Paul A. Hoskisson, Colin Selman, William Harnett
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Tropical Diseases
Subjects:
arthritis
ES-62
gut
haematopoiesis
helminth
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fitd.2023.1334705/full

Internet

https://www.frontiersin.org/articles/10.3389/fitd.2023.1334705/full

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