BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice.

BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice.

BACKGROUND: Inhibition of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is being pursued as a new therapeutic approach for the treatment of obesity and metabolic syndrome. Therefore, there is an urgent need to determine the effect of 11β-HSD1 inhibitor, which suppresses glucocorticoid action, o...

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Bibliographic Details
Main Authors: Long Wang, Juan Liu, Aisen Zhang, Peng Cheng, Xiao Zhang, Shan Lv, Lin Wu, Jing Yu, Wenjuan Di, Juanmin Zha, Xiaocen Kong, Hanmei Qi, Yi Zhong, Guoxian Ding
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3388048?pdf=render

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http://europepmc.org/articles/PMC3388048?pdf=render

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