Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology

Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology

Overexpression of the adenosine A<sub>1</sub> receptor (A<sub>1</sub>AR) has been detected in various cancer cell lines. However, the role of A<sub>1</sub>AR in tumor development is still unclear. Thirteen A<sub>1</sub>AR mutations were identified in t...

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Bibliographic Details
Main Authors: Xuesong Wang, Willem Jespers, Kim A. N. Wolff, Jill Buytelaar, Adriaan P. IJzerman, Gerard J. P. van Westen, Laura H. Heitman
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
G protein-coupled receptors
adenosine A<sub>1</sub> receptor
cancer
mutation
yeast system
Online Access:https://www.mdpi.com/1420-3049/27/12/3742

Internet

https://www.mdpi.com/1420-3049/27/12/3742

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