Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis

Abstract Background Subphenotypes were recently reported within clinical acute respiratory distress syndrome (ARDS), with distinct outcomes and therapeutic responses. Experimental models have long been used to mimic features of ARDS pathophysiology, but the presence of distinct subphenotypes among p...

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Main Authors: Adrien Carla, Bruno Pereira, Hanifa Boukail, Jules Audard, Nathalie Pinol-Domenech, Manuela De Carvalho, Raiko Blondonnet, Ruoyang Zhai, Dominique Morand, Céline Lambert, Vincent Sapin, Lorraine B. Ware, Carolyn S. Calfee, Julie A. Bastarache, John G. Laffey, Nicole P. Juffermans, Lieuwe D. Bos, Antonio Artigas, Patricia R. M. Rocco, Michael A. Matthay, Daniel F. McAuley, Jean-Michel Constantin, Matthieu Jabaudon, for the ESICM Translational Biology Group of the Acute Respiratory Failure section
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Respiratory Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12931-020-01337-9