High-fat and high-glucose microenvironment decreases Runx2 and TAZ expression and inhibits bone regeneration in the mouse

High-fat and high-glucose microenvironment decreases Runx2 and TAZ expression and inhibits bone regeneration in the mouse

Abstract Background Type 2 diabetes mellitus (T2DM) and hyperlipidemia are negatively related to bone regeneration. The aim of this study was to evaluate the effect of high-fat and high-glucose microenvironment on bone regeneration and to detect the expression of runt-related transcription factor 2...

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Bibliographic Details
Main Authors: Xuan Wu, Yunpeng Zhang, Yixiao Xing, Bin Zhao, Cong Zhou, Yong Wen, Xin Xu
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
T2DM (type 2 diabetes mellitus)
Hyperlipidemia
Bone regeneration
Runx2 (runt-related transcription factor 2)
TAZ (transcriptional co-activator with PDZ-binding domain)
Online Access:http://link.springer.com/article/10.1186/s13018-019-1084-2

Internet

http://link.springer.com/article/10.1186/s13018-019-1084-2

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