Comparative Pharmacodynamics of Three Different Botulinum Toxin Type A Preparations following Repeated Intramuscular Administration in Mice

Comparative Pharmacodynamics of Three Different Botulinum Toxin Type A Preparations following Repeated Intramuscular Administration in Mice

Botulinum neurotoxin type A (BoNT/A) causes muscle paralysis by blocking cholinergic signaling at neuromuscular junctions and is widely used to temporarily correct spasticity-related disorders and deformities. The paralytic effects of BoNT/A are time-limited and require repeated injections at regula...

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Bibliographic Details
Main Authors: Jaeyoon Byun, Seongsung Kwak, Jin-Hee Kwon, Minhee Shin, Dong-Kyu Lee, Chang-Hoon Rhee, Won-ho Kang, Jae-Wook Oh, Deu John M. Cruz
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Toxins
Subjects:
botulinum toxin
digit abduction score
compound muscle action potential
repeated injection
duration of action
Online Access:https://www.mdpi.com/2072-6651/14/6/365

Internet

https://www.mdpi.com/2072-6651/14/6/365

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