Human PrimPol Discrimination against Dideoxynucleotides during Primer Synthesis

Human PrimPol Discrimination against Dideoxynucleotides during Primer Synthesis

PrimPol is required to re-prime DNA replication at both nucleus and mitochondria, thus facilitating fork progression during replicative stress. ddC is a chain-terminating nucleotide that has been widely used to block mitochondrial DNA replication because it is efficiently incorporated by the replica...

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Bibliographic Details
Main Authors: Gustavo Carvalho, Alberto Díaz-Talavera, Patricia A. Calvo, Luis Blanco, María I. Martínez-Jiménez
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Genes
Subjects:
PrimPol
DNA primase
polymerase
dideoxynucleotides
CTNA
NRTIs
Online Access:https://www.mdpi.com/2073-4425/12/10/1487

Internet

https://www.mdpi.com/2073-4425/12/10/1487

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