Autophagy Activation Associates with Suppression of Prion Protein and Improved Mitochondrial Status in Glioblastoma Cells

Autophagy Activation Associates with Suppression of Prion Protein and Improved Mitochondrial Status in Glioblastoma Cells

Cells from glioblastoma multiforme (GBM) feature up-regulation of the mechanistic Target of Rapamycin (mTOR), which brings deleterious effects on malignancy and disease course. At the cellular level, up-regulation of mTOR affects a number of downstream pathways and suppresses autophagy, which is rel...

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Bibliographic Details
Main Authors: Paola Lenzi, Carla L. Busceti, Gloria Lazzeri, Rosangela Ferese, Francesca Biagioni, Alessandra Salvetti, Elena Pompili, Valerio De Franchis, Stefano Puglisi-Allegra, Alessandro Frati, Michela Ferrucci, Francesco Fornai
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
mTOR
cytofluorimetry
mitochondrial fission
Pink1
Parkin
Fis1
Online Access:https://www.mdpi.com/2073-4409/12/2/221

Internet

https://www.mdpi.com/2073-4409/12/2/221

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