2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human β3-Adrenergic Activity

2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human β3-Adrenergic Activity

The β3 adrenergic receptor is raising as an important drug target for the treatment of pathologies such as diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selective and high affinity ligands have been made. Currently, Mirabegron is the only available drug...

Full description

Bibliographic Details
Main Authors: Gastón Apablaza, Luisa Montoya, Cesar Morales-Verdejo, Marco Mellado, Mauricio Cuellar, Carlos F. Lagos, Jorge Soto-Delgado, Hery Chung, Carlos David Pessoa-Mahana, Jaime Mella
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Molecules
Subjects:
QSAR
CoMSIA
beta-3 adrenergic receptor
diabetes
obesity
mirabegron
vibegron
indole
Online Access:http://www.mdpi.com/1420-3049/22/3/404

Internet

http://www.mdpi.com/1420-3049/22/3/404

Similar Items