Dual PI3K/mTOR inhibitor PF-04979064 regulates tumor growth in gastric cancer and enhances drug sensitivity of gastric cancer cells to 5-FU

Dual PI3K/mTOR inhibitor PF-04979064 regulates tumor growth in gastric cancer and enhances drug sensitivity of gastric cancer cells to 5-FU

Gastric cancer (GC) is characterized by high tumor heterogeneity, increased surgical difficulty, and limited chemotherapy efficacy, and it is associated with a poor prognosis. The abnormal proliferation of cells involves abnormal activation of the PI3K/AKT/mTOR signaling pathway. Inhibition of this...

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Bibliographic Details
Main Authors: Ziyuan Zhong, Tengkai Wang, Ruochen Zang, Yufei Zang, Yaoyao Feng, Shujun Yan, Congcong Geng, Na Zhu, Qian Wang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Gastric cancer
Targeted therapy
Combination therapy
Proliferation
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222301884X

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http://www.sciencedirect.com/science/article/pii/S075333222301884X

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