Dual PI3K/mTOR inhibitor PF-04979064 regulates tumor growth in gastric cancer and enhances drug sensitivity of gastric cancer cells to 5-FU
Gastric cancer (GC) is characterized by high tumor heterogeneity, increased surgical difficulty, and limited chemotherapy efficacy, and it is associated with a poor prognosis. The abnormal proliferation of cells involves abnormal activation of the PI3K/AKT/mTOR signaling pathway. Inhibition of this...
Main Authors: | Ziyuan Zhong, Tengkai Wang, Ruochen Zang, Yufei Zang, Yaoyao Feng, Shujun Yan, Congcong Geng, Na Zhu, Qian Wang |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2024-01-01
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Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222301884X |
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