O-GlcNAc Transferase Inhibitor Synergistically Enhances Doxorubicin-Induced Apoptosis in HepG2 Cells

O-GlcNAc Transferase Inhibitor Synergistically Enhances Doxorubicin-Induced Apoptosis in HepG2 Cells

The combination of chemotherapy with chemosensitizing agents is a common approach to enhance anticancer activity while reducing the dose-dependent adverse side effects of cancer treatment. Herein, we investigated doxorubicin (DOX) and O-GlcNAc transferase (OGT) inhibitor OSMI-1 combination treatment...

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Bibliographic Details
Main Authors: Su Jin Lee, Oh-Shin Kwon
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
O-GlcNAc transferase inhibitor
doxorubicin
apoptosis
P53
NF-κB
ER stress
Online Access:https://www.mdpi.com/2072-6694/12/11/3154

Internet

https://www.mdpi.com/2072-6694/12/11/3154

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