Control of false discoveries in grouped hypothesis testing for eQTL data

Control of false discoveries in grouped hypothesis testing for eQTL data

Abstract Background Expression quantitative trait locus (eQTL) analysis aims to detect the genetic variants that influence the expression of one or more genes. Gene-level eQTL testing forms a natural grouped-hypothesis testing strategy with clear biological importance. Methods to control family-wise...

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Bibliographic Details
Main Authors: Pratyaydipta Rudra, Yi-Hui Zhou, Andrew Nobel, Fred A. Wright
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Bioinformatics
Subjects:
eQTL
Grouped hypothesis testing
False discovery rate
Empirical Bayes
Online Access:https://doi.org/10.1186/s12859-024-05736-3

Internet

https://doi.org/10.1186/s12859-024-05736-3

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