Reduction of oxytocin-containing neurons and enhanced glymphatic activity in the hypothalamic paraventricular nucleus of patients with type 2 diabetes mellitus

Reduction of oxytocin-containing neurons and enhanced glymphatic activity in the hypothalamic paraventricular nucleus of patients with type 2 diabetes mellitus

Abstract Evidence from animal experiments has shown that the hypothalamic paraventricular nucleus (PVN) plays a key role in regulating body weight and blood glucose levels. However, it is unclear whether neuron populations in the human PVN are involved in the development of type 2 diabetes mellitus...

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Bibliographic Details
Main Authors: Felipe Correa-da-Silva, Martin J. Kalsbeek, Femke S. Gadella, Jorn Oppersma, Wei Jiang, Samantha E. C. Wolff, Nikita L. Korpel, Dick F. Swaab, Eric Fliers, Andries Kalsbeek, Chun-Xia Yi
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Acta Neuropathologica Communications
Subjects:
Hypothalamus
Oxytocin
Type 2 diabetes mellitus
Astrocytes
Glymphatic
Insulin resistance
Online Access:https://doi.org/10.1186/s40478-023-01606-w

Internet

https://doi.org/10.1186/s40478-023-01606-w

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