The PROVIT Study—Effects of Multispecies Probiotic Add-on Treatment on Metabolomics in Major Depressive Disorder—A Randomized, Placebo-Controlled Trial

The PROVIT Study—Effects of Multispecies Probiotic Add-on Treatment on Metabolomics in Major Depressive Disorder—A Randomized, Placebo-Controlled Trial

The gut–brain axis plays a role in major depressive disorder (MDD). Gut-bacterial metabolites are suspected to reduce low-grade inflammation and influence brain function. Nevertheless, randomized, placebo-controlled probiotic intervention studies investigating metabolomic changes in patients with MD...

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Bibliographic Details
Main Authors: Kathrin Kreuzer, Alexandra Reiter, Anna Maria Birkl-Töglhofer, Nina Dalkner, Sabrina Mörkl, Marco Mairinger, Eva Fleischmann, Frederike Fellendorf, Martina Platzer, Melanie Lenger, Tanja Färber, Matthias Seidl, Armin Birner, Robert Queissner, Lilli-Marie Stefanie Mendel, Alexander Maget, Alexandra Kohlhammer-Dohr, Alfred Häussl, Jolana Wagner-Skacel, Helmut Schöggl, Daniela Amberger-Otti, Annamaria Painold, Theresa Lahousen-Luxenberger, Brigitta Leitner-Afschar, Johannes Haybaeck, Hansjörg Habisch, Tobias Madl, Eva Reininghaus, Susanne Bengesser
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Metabolites
Subjects:
depression
gut–brain-axis
probiotics
metabolomics
NMR spectroscopy
butyrate
Online Access:https://www.mdpi.com/2218-1989/12/8/770

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https://www.mdpi.com/2218-1989/12/8/770

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