NEDD4L in human tumors: regulatory mechanisms and dual effects on anti-tumor and pro-tumor

Tumorigenesis and tumor development are closely related to the abnormal regulation of ubiquitination. Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L), an E3 ubiquitin ligase critical to the ubiquitination process, plays key roles in the regulation of cancer stem cells,...

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Bibliographic Details
Main Authors: Meng Zhang, Zhenyong Zhang, Xin Tian, Enchong Zhang, Yichun Wang, Jun Tang, Jianzhu Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1291773/full