Successful Profiling of Plasmodium falciparum var Gene Expression in Clinical Samples via a Custom Capture Array

Successful Profiling of Plasmodium falciparum var Gene Expression in Clinical Samples via a Custom Capture Array

ABSTRACT var genes encode Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens. These highly diverse antigens are displayed on the surface of infected erythrocytes and play a critical role in immune evasion and sequestration of infected erythrocytes. Studies of var expression using...

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Bibliographic Details
Main Authors: Emily M. Stucke, Antoine Dara, Ankit Dwivedi, Theresa K. Hodges, Sandra Ott, Drissa Coulibaly, Abdoulaye K. Koné, Karim Traoré, Bouréima Guindo, Bourama M. Tangara, Amadou Niangaly, Modibo Daou, Issa Diarra, Youssouf Tolo, Mody Sissoko, Luke J. Tallon, Lisa Sadzewicz, Albert E. Zhou, Matthew B. Laurens, Amed Ouattara, Bourema Kouriba, Ogobara K. Doumbo, Shannon Takala-Harrison, David Serre, Christopher V. Plowe, Mahamadou A. Thera, Mark A. Travassos, Joana C. Silva
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:mSystems
Subjects:
P. falciparum
malaria
PfEMP1
var gene
Plasmodium falciparum
RNA-Seq
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00226-21

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https://journals.asm.org/doi/10.1128/mSystems.00226-21

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