Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties

Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties

Cathepsin D (CTSD) is a lysosomal protease important for the degradation of various substrates, including disease-associated proteins like α-synuclein (a-syn), amyloid precursor protein (APP) and tau, all of which tend to aggregate if not efficiently degraded. Hence, it is not surprising that geneti...

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Bibliographic Details
Main Authors: Josina Bunk, Susy Prieto Huarcaya, Alice Drobny, Jan Philipp Dobert, Lina Walther, Stefan Rose-John, Philipp Arnold, Friederike Zunke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
lysosomal degradation
molecular dynamics simulation
Parkinson’s disease
neuronal ceroid lipofuscinoses
lysosomes
alpha-synuclein
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.581805/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.581805/full

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