Effect of Arylazo Sulfones on DNA: Binding, Cleavage, Photocleavage, Molecular Docking Studies and Interaction with A375 Melanoma and Non-Cancer Cells

Effect of Arylazo Sulfones on DNA: Binding, Cleavage, Photocleavage, Molecular Docking Studies and Interaction with A375 Melanoma and Non-Cancer Cells

A set of arylazo sulfones, known to undergo N–S bond cleavage upon light exposure, has been synthesized, and their activity in the dark and upon irradiation towards DNA has been investigated. Their interaction with calf-thymus DNA has been examined, and the significant affinity observed (most probab...

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Bibliographic Details
Main Authors: Chrysoula Mikra, Achilleas Mitrakas, Virginia Ghizzani, Katerina R. Katsani, Maria Koffa, Michael Koukourakis, George Psomas, Stefano Protti, Maurizio Fagnoni, Konstantina C. Fylaktakidou
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
arylazo sulfones
DNA binding
DNA cleavage
DNA photocleavage
A375 melanoma cells
molecular docking
Online Access:https://www.mdpi.com/1422-0067/24/3/1834

Internet

https://www.mdpi.com/1422-0067/24/3/1834

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