Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

Abstract Background Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain, prior and a...

Full description

Bibliographic Details
Main Authors: Antonella Tramutola, Chiara Lanzillotta, Eugenio Barone, Andrea Arena, Ilaria Zuliani, Luciana Mosca, Carla Blarzino, D. Allan Butterfield, Marzia Perluigi, Fabio Di Domenico
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Translational Neurodegeneration
Subjects:
mTOR
Autophagy
Rapamycin
Down syndrome
Alzheimer disease
APP
Online Access:http://link.springer.com/article/10.1186/s40035-018-0133-9

Internet

http://link.springer.com/article/10.1186/s40035-018-0133-9

Similar Items