Trabectedin modulates macrophage polarization in the tumor-microenvironment. Role of KV1.3 and KV1.5 channels

Trabectedin modulates macrophage polarization in the tumor-microenvironment. Role of KV1.3 and KV1.5 channels

Immune cells have an important role in the tumor-microenvironment. Macrophages may tune the immune response toward inflammatory or tolerance pathways. Tumor-associated macrophages (TAM) have a string of immunosuppressive functions and they are considered a therapeutic target in cancer. This study ai...

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Bibliographic Details
Main Authors: Diego A. Peraza, Adrián Povo-Retana, Marina Mojena, Ana B. García-Redondo, Pablo Avilés, Lisardo Boscá, Carmen Valenzuela
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Macrophages
Trabectedin
Cancer
TAMs
KV1.3
KV1.5
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223003360

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http://www.sciencedirect.com/science/article/pii/S0753332223003360

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