Preclinical evaluation of immunogenicity and protective efficacy of a recombinant chimeric protein vaccine against visceral leishmaniasis

Preclinical evaluation of immunogenicity and protective efficacy of a recombinant chimeric protein vaccine against visceral leishmaniasis

Visceral leishmaniasis (VL) is a tropical disease that can be fatal if acute and untreated. Diagnosis is difficult, the treatment is toxic and prophylactic vaccines do not exist. Leishmania parasites express hundreds of proteins and several of them are relevant for the host's immune system. In...

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Bibliographic Details
Main Authors: Daniela P. Lage, Danniele L. Vale, Fabiana A. G. Maia, Vívian T. Martins, Marcela G. P. Silva, Nathalia C. Galvani, Mariana M. Cardoso, Gabriel J. L. Moreira, Eduarda M. Sombrio, Camila S. Freitas, Breno L. Pimenta, Karolina O. M. Falcão, Saulo S. G. Dias, Raquel S. Bandeira, Isabela A. G. Pereira, Grasiele S. V. Tavares, Antônio L. Teixeira, Miguel A. Chávez-Fumagalli, Bruno M. Roatt, Ricardo A. Machado-de-Ávila, Eduardo A. F. Coelho
Format: Article
Language:English
Published: Cambridge University Press
Series:Parasitology
Subjects:
chimera
immune response
lymphoproliferation
T-cell epitopes
vaccine
visceral leishmaniasis
Online Access:https://www.cambridge.org/core/product/identifier/S0031182024001240/type/journal_article

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https://www.cambridge.org/core/product/identifier/S0031182024001240/type/journal_article

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