CAR-modified Cellular Therapies in Chronic Lymphocytic Leukemia: Is the Uphill Road Getting Less Steep?

The clinical development of chimeric antigen receptor (CAR) T-cell therapy has been more challenging for chronic lymphocytic leukemia (CLL) compared to other settings. One of the main reasons is the CLL-associated state of immune dysfunction that specifically involves patient-derived T cells. Here,...

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Bibliographic Details
Main Authors: Candida Vitale, Valentina Griggio, Francesca Perutelli, Marta Coscia
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000988