Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

Cdc48/p97 is a key component of the ubiquitin-proteasome system, acting as a ubiquitin-directed segregase to regulate multiple cellular functions. Here the authors identify UBXN-3/FAF1 as a crucial regulator of chromatin-associated protein degradation that recruits Cdc48/p97 to DNA replication forks...

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Bibliographic Details
Main Authors: André Franz, Paul A. Pirson, Domenic Pilger, Swagata Halder, Divya Achuthankutty, Hamid Kashkar, Kristijan Ramadan, Thorsten Hoppe
Format: Article
Language:English
Published: Nature Portfolio 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10612

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https://doi.org/10.1038/ncomms10612

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