Ribosome profiling reveals downregulation of UMP biosynthesis as the major early response to phage infection

Ribosome profiling reveals downregulation of UMP biosynthesis as the major early response to phage infection

ABSTRACTBacteria have evolved diverse defense mechanisms to counter bacteriophage attacks. Genetic programs activated upon infection characterize phage–host molecular interactions and ultimately determine the outcome of the infection. In this study, we applied ribosome profiling to monitor protein s...

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Bibliographic Details
Main Authors: Patrick B. F. O’Connor, Jennifer Mahony, Eoghan Casey, Pavel V. Baranov, Douwe van Sinderen, Martina M. Yordanova
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
ribosome profiling
mRNA translation
anti-phage response
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03989-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03989-23

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