Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene

Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene

Abstract Background From the first steps of prostate cancer (PCa) initiation, tumours are in contact with the most-proximal adipose tissue called periprostatic adipose tissue (PPAT). Extracellular vesicles are important carriers of non-coding RNA such as miRNAs that are crucial for cellular communic...

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Bibliographic Details
Main Authors: Silvia Sánchez-Martin, Antonio Altuna-Coy, Verónica Arreaza-Gil, Xana Bernal-Escoté, Joan Francesc Garcia Fontgivell, Helena Ascaso-Til, José Segarra-Tomás, Xavier Ruiz-Plazas, Matilde R. Chacón
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Journal of Translational Medicine
Subjects:
Periprostatic adipose tissue
Exovesicles
miRNAs
Prostate cancer
RORA gene
Online Access:https://doi.org/10.1186/s12967-024-05458-3

Internet

https://doi.org/10.1186/s12967-024-05458-3

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