Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

The universal second messenger cAMP regulates diverse intracellular processes by interacting with ubiquitously expressed proteins, such as Protein Kinase A (PKA) and the Exchange Protein directly Activated by cAMP (EPAC). EPAC is implicated in multiple pathologies, thus several EPAC-specific inhibit...

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Bibliographic Details
Main Authors: Alveena Ahmed, Stephen Boulton, Hongzhao Shao, Madoka Akimoto, Amarnath Natarajan, Xiaodong Cheng, Giuseppe Melacini
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cells
Subjects:
epac
aggregation-based inhibition
allostery
camp
dynamics
drug design
nmr
protein-ligand binding
screening
signaling
Online Access:https://www.mdpi.com/2073-4409/8/11/1462

Internet

https://www.mdpi.com/2073-4409/8/11/1462

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