Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation

Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation

Colorectal cancer (CRC) is a common, multifactorial disease. While observational studies have identified an association between lower vitamin D and higher CRC risk, supplementation trials have been inconclusive and the mechanisms by which vitamin D may modulate CRC risk are not well understood. We s...

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Bibliographic Details
Main Authors: James P. Blackmur, Peter G. Vaughan-Shaw, Kevin Donnelly, Bradley T. Harris, Victoria Svinti, Anna-Maria Ochocka-Fox, Paz Freile, Marion Walker, Toby Gurran, Stuart Reid, Colin A. Semple, Farhat V. N. Din, Maria Timofeeva, Malcolm G. Dunlop, Susan M. Farrington
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Genetics
Subjects:
colorectal cancer
vitamin D
vitamin D supplementation
gene correlation network
WGCNA (weighted gene co-expression network analysis)
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.783970/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.783970/full

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