Dichloroacetate enhances sorafenib's inhibitory effect on proliferation of hepatocellular carcinoma cells by activating ROS-JNK pathway

Dichloroacetate enhances sorafenib's inhibitory effect on proliferation of hepatocellular carcinoma cells by activating ROS-JNK pathway

Objective To investigate the synergistic effect of dichloroacetate (DCA) and sorafenib on the inhibition of proliferation in hepatocellular carcinoma (HCC) cells. Methods Hep3B cells were treated respectively, with DMSO (control), DCA (5 mmol/L), sorafenib (10 μmol/L), and DCA (5 mmol/L) combined wi...

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Bibliographic Details
Main Authors: SUN Liangbo, YAO Jie, LI Tao
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2019-09-01
Series:Di-san junyi daxue xuebao
Subjects:
dichloroacetate
sorafenib
hepatocellular carcinoma
cell proliferation
ros/jnk signal pathway
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/201904059.htm

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http://aammt.tmmu.edu.cn/Upload/rhtml/201904059.htm

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