Dynamic Monitoring of Intracellular Tacrolimus and Mycophenolic Acid Therapy in Renal Transplant Recipients Using Magnetic Bead Extraction Combined with LC-MS/MS

Dynamic Monitoring of Intracellular Tacrolimus and Mycophenolic Acid Therapy in Renal Transplant Recipients Using Magnetic Bead Extraction Combined with LC-MS/MS

Background: Tacrolimus (TAC) and mycophenolic acid (MPA) are commonly used immunosuppressive therapies after renal transplant. Our objective was to quantify TAC and MPA concentrations in peripheral blood mononuclear cells (PBMCs) using liquid chromatography tandem mass spectrometry (LC-MS/MS) and to...

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Bibliographic Details
Main Authors: Huan Xu, Yingying Liu, Yinan Zhang, Xinhua Dai, Xueqiao Wang, Haojun Chen, Lin Yan, Xingxin Gong, Jiaxi Yue, Zhengli Wan, Jiwen Fan, Yangjuan Bai, Yao Luo, Yi Li
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceutics
Subjects:
renal transplant
tacrolimus
mycophenolic acid
peripheral blood mononuclear cell
LC-MS/MS
Online Access:https://www.mdpi.com/1999-4923/15/9/2318

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https://www.mdpi.com/1999-4923/15/9/2318

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