NANOG initiates epiblast fate through the coordination of pluripotency genes expression

NANOG initiates epiblast fate through the coordination of pluripotency genes expression

Pluripotent epiblast cells segregate from primitive endoderm in the blastocyst inner cell mass (ICM). Here the authors show that mosaic epiblast differentiation during mouse and human preimplantation development initiates stochastically in ICM progenitors, independently of the FGF pathway, and requi...

Full description

Bibliographic Details
Main Authors: Nicolas Allègre, Sabine Chauveau, Cynthia Dennis, Yoan Renaud, Dimitri Meistermann, Lorena Valverde Estrella, Pierre Pouchin, Michel Cohen-Tannoudji, Laurent David, Claire Chazaud
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30858-8

Internet

https://doi.org/10.1038/s41467-022-30858-8

Similar Items