Restoring functional TDP-43 oligomers in ALS and laminopathic cellular models through baicalein-induced reconfiguration of TDP-43 aggregates

Restoring functional TDP-43 oligomers in ALS and laminopathic cellular models through baicalein-induced reconfiguration of TDP-43 aggregates

Abstract A group of misfolded prone-to-aggregate domains in disease-causing proteins has recently been shown to adopt unique conformations that play a role in fundamental biological processes. These processes include the formation of membrane-less sub-organelles, alternative splicing, and gene activ...

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Bibliographic Details
Main Authors: Hsiang-Yu Chang, I-Fan Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Baicalein
TDP-43
Physiological oligomers
FTLD-U
ALS
Low complexity (LC) domain
Online Access:https://doi.org/10.1038/s41598-024-55229-9

Internet

https://doi.org/10.1038/s41598-024-55229-9

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