Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment

Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment

Growing evidence shows that nerves play an active role in cancer development and progression by altering crucial molecular pathways and cell functions. Conversely, the use of neurotropic drugs, such as tricyclic antidepressants (TCAs), may modulate these molecular signals with a therapeutic purpose...

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Bibliographic Details
Main Authors: Antonio Asensi-Cantó, María Dolores López-Abellán, Verónica Castillo-Guardiola, Ana María Hurtado, Mónica Martínez-Penella, Ginés Luengo-Gil, Pablo Conesa-Zamora
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
tricyclic antidepressants
antitumor therapy
imipramine
central nervous system
drug repurposing
Online Access:https://www.mdpi.com/2072-6694/14/13/3248

Internet

https://www.mdpi.com/2072-6694/14/13/3248

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