The architecture of EMC reveals a path for membrane protein insertion

The architecture of EMC reveals a path for membrane protein insertion

Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein complex termed EMC has been implicated in membrane protein biogenesis, but its mechanism of action is poorly understood. Here, we...

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Bibliographic Details
Main Authors: John P O'Donnell, Ben P Phillips, Yuichi Yagita, Szymon Juszkiewicz, Armin Wagner, Duccio Malinverni, Robert J Keenan, Elizabeth A Miller, Ramanujan S Hegde
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
endoplasmic reticulum
membrane proteins
organelle biogenesis
chaperone
Online Access:https://elifesciences.org/articles/57887

Internet

https://elifesciences.org/articles/57887

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