Transferrin epitope-CD19-CAR-T cells effectively kill lymphoma cells in vitro and in vivo

Transferrin epitope-CD19-CAR-T cells effectively kill lymphoma cells in vitro and in vivo

Chimeric antigen receptor (CAR) T cell immunotherapy has demonstrated clinical success in treatment of B-cell hematologic cancers. In this study, we compared human Transferrin epitope tagged CAR-T cells with non-tagged CAR-T cells for cytotoxicity, IFN-gamma secretion and tumor clearance in NSG mice...

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Bibliographic Details
Main Authors: Michael Valentine, Le Li, Hua Zhou, Shirley Xu, Jinying Sun, Chengjing Liu, Hizkia Harto, Robert Berahovich, Vita Golubovskaya, Lijun Wu
Format: Article
Language:English
Published: IMR Press 2020-01-01
Series:Frontiers in Bioscience-Landmark
Subjects:
chimeric antigen receptor
immunotherapy
epitope
transferrin
cd19
cd22
Online Access:https://www.imrpress.com/journal/FBL/25/2/10.2741/4806

Internet

https://www.imrpress.com/journal/FBL/25/2/10.2741/4806

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