Passive Transfer of Blood Sera from ALS Patients with Identified Mutations Results in Elevated Motoneuronal Calcium Level and Loss of Motor Neurons in the Spinal Cord of Mice

Passive Transfer of Blood Sera from ALS Patients with Identified Mutations Results in Elevated Motoneuronal Calcium Level and Loss of Motor Neurons in the Spinal Cord of Mice

<b>Introduction:</b> Previously, we demonstrated the degeneration of axon terminals in mice after repeated injections of blood sera from amyotrophic lateral sclerosis (ALS) patients with identified mutations. However, whether a similar treatment affects the cell body of motor neurons (MN...

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Main Authors: Tamás F. Polgár, Valéria Meszlényi, Bernát Nógrádi, Laura Körmöczy, Krisztina Spisák, Kornélia Tripolszki, Márta Széll, Izabella Obál, József I. Engelhardt, László Siklós, Roland Patai
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
passive transfer
blood serum
motoneuronal calcium increase
motoneuronal loss
<i>C9ORF72</i>
Online Access:https://www.mdpi.com/1422-0067/22/18/9994

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https://www.mdpi.com/1422-0067/22/18/9994

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