Amodiaquine promotes testosterone production and de novo synthesis of cholesterol and triglycerides in Leydig cells

Amodiaquine promotes testosterone production and de novo synthesis of cholesterol and triglycerides in Leydig cells

Testosterone is a hormone essential for male reproductive function. It is produced primarily by Leydig cells in the testicle through activation of steroidogenic acute regulatory protein and a series of steroidogenic enzymes, including a cytochrome P450 side-chain cleavage enzyme (cytochome P450 fami...

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Bibliographic Details
Main Authors: Yujeong Choi, Eun Goo Lee, Gibbeum Lee, Mi Gyeong Jeong, Hyo Kyeong Kim, Ji-Hyun Oh, Sung Won Kwon, Eun Sook Hwang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
amodiaquine
cholesterol synthesis
lipidomics
nuclear receptor 4A1
steroidogenesis
steroidogenic acute regulatory protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227521001358

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http://www.sciencedirect.com/science/article/pii/S0022227521001358

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