METTL14-mediated Lnc-LSG1 m6A modification inhibits clear cell renal cell carcinoma metastasis via regulating ESRP2 ubiquitination

METTL14-mediated Lnc-LSG1 m6A modification inhibits clear cell renal cell carcinoma metastasis via regulating ESRP2 ubiquitination

Clear cell renal cell carcinoma (ccRCC) is the most lethal urological cancer and is characterized by a high rate of metastasis and relapse. N6-Methyladenosine (m6A) is implicated in various stages of cancer development. However, a thorough understanding of m6A-modified lncRNAs in ccRCC is lacking. T...

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Bibliographic Details
Main Authors: Danyang Shen, Lifeng Ding, Zeyi Lu, Ruyue Wang, Chenhao Yu, Huan Wang, Qiming Zheng, Xuliang Wang, Wanjiang Xu, Haifeng Yu, Liwei Xu, Mingchao Wang, Shicheng Yu, Shibin Zhu, Jun Qian, Liqun Xia, Gonghui Li
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
clear cell renal cell carcinoma
N6-methyladenosine
METTL14
YTHDC1
Lnc-LSG1
ESRP2
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121003279

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http://www.sciencedirect.com/science/article/pii/S2162253121003279

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