Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction

Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction

Summary: Type I interferons (IFNs) increase the excitability of dorsal root ganglia (DRGs) neurons via MNK-eIF4E signaling to promote pain sensitization in mice. Activation of stimulator of interferon response cGAMP interactor 1 (STING) signaling is pivotal for type I IFN induction. We hypothesized...

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Bibliographic Details
Main Authors: Úrzula Franco-Enzástiga, Keerthana Natarajan, Eric T. David, Krish Patel, Abhira Ravirala, Theodore J. Price
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Molecular neuroscience
Cellular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224000294

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http://www.sciencedirect.com/science/article/pii/S2589004224000294

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