FKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2α blockade by facilitating LDHA phosphorylation

FKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2α blockade by facilitating LDHA phosphorylation

Abstract Renal cell carcinoma (RCC) is one of the three major malignant tumors of the urinary system and originates from proximal tubular epithelial cells. Clear cell renal cell carcinoma (ccRCC) accounts for approximately 80% of RCC cases and is recognized as a metabolic disease driven by genetic m...

Full description

Bibliographic Details
Main Authors: Ren Liu, Zhihao Zou, Lingwu Chen, Yuanfa Feng, Jianheng Ye, Yulin Deng, Xuejin Zhu, Yixun Zhang, Jundong Lin, Shanghua Cai, Zhenfeng Tang, Yingke Liang, Jianming Lu, Yangjia Zhuo, Zhaodong Han, Xiaohui Ling, Yuxiang Liang, Zongren Wang, Weide Zhong
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06450-x

Internet

https://doi.org/10.1038/s41419-024-06450-x

Similar Items