Improved Induction of Anti-Melanoma T Cells by Adenovirus-5/3 Fiber Modification to Target Human DCs

Improved Induction of Anti-Melanoma T Cells by Adenovirus-5/3 Fiber Modification to Target Human DCs

To mount a strong anti-tumor immune response, non T cell inflamed (cold) tumors may require combination treatment encompassing vaccine strategies preceding checkpoint inhibition. In vivo targeted delivery of tumor-associated antigens (TAA) to dendritic cells (DCs), relying on the natural functions o...

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Bibliographic Details
Main Authors: Dafni Chondronasiou, Tracy-Jane T. H. D. Eisden, Anita G. M. Stam, Qiana L. Matthews, Mert Icyuz, Erik Hooijberg, Igor Dmitriev, David T. Curiel, Tanja D. de Gruijl, Rieneke van de Ven
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Vaccines
Subjects:
melanoma
adenovirus (Ad)5/3
dendritic cell targeting
melanoma-specific T cells
MART-1
sentinel lymph node
Online Access:http://www.mdpi.com/2076-393X/6/3/42

Internet

http://www.mdpi.com/2076-393X/6/3/42

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