Gut microbiota-mediated C-sulfonate metabolism impairs the bioavailability and anti-cholestatic efficacy of andrographolide

Gut microbiota-mediated C-sulfonate metabolism impairs the bioavailability and anti-cholestatic efficacy of andrographolide

Cholestatic liver injury results from the accumulation of toxic bile acids in the liver, presenting a therapeutic challenge with no effective treatment available to date. Andrographolide (AP) has exhibited potential as a treatment for cholestatic liver disease. However, its limited oral bioavailabil...

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Bibliographic Details
Main Authors: Dafu Tang, Wanyu Hu, Bingxuan Fu, Xiaojie Zhao, Guoquan You, Cong Xie, Hong Yu Wang, Xueni Guo, Qianbing Zhang, Zhongqiu Liu, Ling Ye
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Gut Microbes
Subjects:
Andrographolide
C-sulfonate metabolism
gut microbiota
oral bioavailability
anti-cholestatic effect
APS reductase
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2024.2387402

Internet

https://www.tandfonline.com/doi/10.1080/19490976.2024.2387402

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