Deep mutational scanning of proteins in mammalian cells

Summary: Protein mutagenesis is essential for unveiling the molecular mechanisms underlying protein function in health, disease, and evolution. In the past decade, deep mutational scanning methods have evolved to support the functional analysis of nearly all possible single-amino acid changes in a p...

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Bibliographic Details
Main Authors: Stefanie Maes, Nick Deploey, Frank Peelman, Sven Eyckerman
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports: Methods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667237523003120