NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β‐dependent regulation of PLK4

NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β‐dependent regulation of PLK4

The AMP‐activated protein kinase (AMPK)‐related kinase NUAK1 (NUAK family SNF1‐like kinase 1) has emerged as a potential vulnerability in MYC‐dependent cancer but the biological roles of NUAK1 in different settings are poorly characterised, and the spectrum of cancer types that exhibit a requirement...

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Bibliographic Details
Main Authors: Declan Whyte, George Skalka, Peter Walsh, Ania Wilczynska, Nikki R. Paul, Claire Mitchell, Colin Nixon, William Clarke, Martin Bushell, Jennifer P. Morton, Daniel J. Murphy, Nathiya Muthalagu
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Molecular Oncology
Subjects:
centrosome replication
genomic instability
GSK3β
MYPT1
NUAK1
PDAC
Online Access:https://doi.org/10.1002/1878-0261.13425

Internet

https://doi.org/10.1002/1878-0261.13425

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