Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model.

Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model.

Mutations in the apicobasal polarity gene CRB1 lead to diverse retinal diseases, such as Leber congenital amaurosis, cone-rod dystrophy, retinitis pigmentosa (with and without Coats-like vasculopathy), foveal retinoschisis, macular dystrophy, and pigmented paravenous chorioretinal atrophy. Limited c...

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Bibliographic Details
Main Authors: Sonia M Weatherly, Gayle B Collin, Jeremy R Charette, Lisa Stone, Nattaya Damkham, Lillian F Hyde, James G Peterson, Wanda Hicks, Gregory W Carter, Jürgen K Naggert, Mark P Krebs, Patsy M Nishina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009798

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https://doi.org/10.1371/journal.pgen.1009798

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