Single cell lineage reconstruction using distance-based algorithms and the R package, DCLEAR

Single cell lineage reconstruction using distance-based algorithms and the R package, DCLEAR

Abstract Background DCLEAR is an R package used for single cell lineage reconstruction. The advances of CRISPR-based gene editing technologies have enabled the prediction of cell lineage trees based on observed edited barcodes from each cell. However, the performance of existing reconstruction metho...

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Bibliographic Details
Main Authors: Wuming Gong, Hyunwoo J. Kim, Daniel J. Garry, Il-Youp Kwak
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Bioinformatics
Subjects:
Cell lineage tracing
Lineage reconstruction
Machine learning
Simulation
Online Access:https://doi.org/10.1186/s12859-022-04633-x

Internet

https://doi.org/10.1186/s12859-022-04633-x

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