Porcine Epidemic Diarrhea Virus (PEDV) ORF3 Enhances Viral Proliferation by Inhibiting Apoptosis of Infected Cells

The genomes of coronaviruses carry accessory genes known to be associated with viral virulence. The single accessory gene of porcine epidemic diarrhea virus (PEDV), ORF3, is dispensable for virus replication in vitro, while viral mutants carrying ORF3 truncations exhibit an attenuated phenotype of w...

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Bibliographic Details
Main Authors: Fusheng Si, Xiaoxia Hu, Chenyang Wang, Bingqing Chen, Ruiyang Wang, Shijuan Dong, Ruisong Yu, Zhen Li
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/12/2/214