A Critical Role for the Putative NCS2 Nucleobase Permease YjcD in the Sensitivity of <named-content content-type="genus-species">Escherichia coli</named-content> to Cytotoxic and Mutagenic Purine Analogs
ABSTRACT The base analogs 6-N-hydroxylaminopurine (HAP) and 2-amino-HAP (AHAP) are potent mutagens in bacteria and eukaryotic organisms. Previously, we demonstrated that a defect in the Escherichia coli ycbX gene, encoding a molybdenum cofactor-dependent oxidoreductase, dramatically enhances sensiti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2013-12-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.00661-13 |