Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR

Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR

Alterations in the balance between skeletogenesis and adipogenesis is a pathogenic feature in multiple skeletal disorders. Clinically, enhanced bone marrow adiposity in bones impairs mobility and increases fracture risk, reducing the quality of life of patients. The molecular mechanism that underlie...

Full description

Bibliographic Details
Main Authors: Fabiana Csukasi, Michaela Bosakova, Tomas Barta, Jorge H. Martin, Jesus Arcedo, Maya Barad, Gustavo A. Rico-Llanos, Jennifer Zieba, Jose Becerra, Pavel Krejci, Ivan Duran, Deborah Krakow
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DEPTOR
TAZ
osteogenesis
PTH signaling
Wnt
skeletal differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.963389/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.963389/full

Similar Items